The filmmakers interviewed close to 100 gap-toothed women ranging in age from 18 months to 88 years, 40 of whom appear in the film, to find out what makes them tick - their interests, beliefs, lifestyles, and whether or not a space in one's teeth can make a difference. As in Les Blank's GARLIC IS AS GOOD AS TEN MOTHERS, what seems to be a trivial subject forms an arena for the exploration of cross currents of human nature.

"In addition to gap-teeth, which affected each interviewee differently, these women have senses of humor and proportion that make them extraordinarily good company. More or less in passing without half-trying, GAP-TOOTHED WOMEN also becomes a celebration of womanhood."
- Vincent Canby, The New York Times